Clopid-As (75mg+75mg) Tablet

✔️ Uses of Clopid-As Tablet

Prevention of Heart Attack and Stroke.

✔️ How does Clopid-As Tablet work?

Clopid-As Tablet is a combination of two antiplatelet medicines: Aspirin and Clopidogrel which prevent heart attack. They work by preventing the platelets from sticking together and decreasing the formation of harmful blood clots.

✔️ Side Effects of Clopid-As Tablet

Common side effects include bleeding, diarrhea, stomach pain, hemorrhage, and skin reactions. Rare side effects include acquired hemophilia, anemia, angioedema, arthralgia, arthritis, and bone marrow abnormalities.

✔️ Quick Suggestions:

• Adhere to a regular schedule for consistent intake.
• Do not use other over-the-counter medications, herbal, or vitamin supplements without informing your pharmacist or doctor.
• Keep cholesterol and triglyceride levels under control through appropriate measures.
• Eat at regular intervals.
• Follow a healthy diet that includes fresh fruits and vegetables.
• Restrict alcohol consumption as it can raise blood pressure and increase the risk of heart disease.
• Keep a check on your weight.
• Incorporate regular exercise into your routine to maintain heart health.
• Learn from your doctor how to recognize and manage early symptoms of heart disease.
• Inform your doctor if you have a scheduled surgery.
• This medicine may increase the risk of bleeding, and your doctor will guide managing this risk during surgical procedures.

✔️ Indications:

Clopid-AS, a blood thinner or a combination of two antiplatelet medications, is prescribed to reduce the risk of dangerous blood clots in blood vessels. It is beneficial for individuals with heart disease, helping prevent heart attacks or strokes. The medication should be taken consistently at regular intervals, preferably with food, as directed by the doctor.

✔️ Pharmacology

Clopidogrel, the active ingredient, inhibits platelet activation and aggregation by binding irreversibly to platelet P2Y12 ADP receptors. A single oral dose can dosage-dependently inhibit platelet aggregation two hours later. Repeated doses of 75 mg per day lead to a stable antiplatelet effect between Days 3 and 7.

✔️ Dosage & Administration of Clopid-As Tablet

• For patients needing an antiplatelet effect within hours, start with a single 300 mg (4 tablets) oral loading dose, followed by 75 mg once daily.
• For recent MI, recent stroke, or established peripheral arterial disease: 75 mg once daily orally without a loading dose.
• It can be taken orally with or without food.

✔️ Interaction

• NSAIDs, warfarin, SSRIs, SNRIs: Increases the risk of bleeding.
• Inhibitors of CYP2C19 (omeprazole or esomeprazole): Avoid concurrent use.
• Clopidogrel (CYP2C8 substrates): Avoid using concurrently with Repaglinide.

✔️ Contraindications

Clopid is contraindicated in individuals with hypersensitivity to any component, the medication substance, or active pathological bleeding, such as cerebral hemorrhage or peptic ulcer.

✔️ Pregnancy & Lactation

• No well-controlled trials in pregnant women; use only if necessary.
• Not known to be excreted in human breast milk; a decision should be made whether to cease breastfeeding or the drug, considering its relevance to the mother.

✔️ Precautions & Warnings

• Genetic variants and drugs blocking CYP2C19 may interfere with metabolism.
• The risk of bleeding may increase; platelet transfusions may be less successful in restoring hemostasis.
• Discontinuation increases the risk of cardiovascular events.
• Reports of TTP require immediate medical attention.
• Increased risk of bleeding; caution with sharp objects.
• Temporary discontinuation may be required for surgeries or dental procedures.

✔️ Storage Conditions

Keep in a dry area below 30°C, away from light. Do not freeze. Keep out of children's reach.